Ft. Detrick
Standard
June 23, 2005
USAMRIID
ready for 'new era in biodefense'
Commander looks
back at successes, challenges
by Caree Vander Linden
U.S. Army Medical Research Institute
of Infectious Diseases
This article is the first of
a two-part series on USAMRIID transformation based on interviews with Col.
Erik A. Henchal, outgoing commander of the Institute. In Part I, Henchal
talks about the events following 9/11 that served as a catalyst for change
at the Nation's premier biodefense laboratory, followed by a discussion
of biosurety, safety, physical plant issues, and the National Interagency
Biodefense Campus. The second and final article will appear in the July
7th issue of The Standard.
On June 20, 2005, Col. Erik A.
Henchal relinquished command of the U.S. Army Medical Research Institute
of Infectious Diseases, the nation's lead biodefense laboratory and his
professional home for the past 13 years. Reflecting on his three years
as commander, he said he's proud of the Institute's achievements and its
continuing effort to transform itself to meet new demands in the post-9/11
world.
Henchal took the helm in June
2002--a particularly challenging time in the Institute's history. Following
the anthrax mail attacks of October 2001, USAMRIID was used as a confirmatory
site for identifying and characterizing anthrax spores. As chief of the
Diagnostic Systems Division at that time, Henchal oversaw an operation
in which USAMRIID processed over 30,000 samples and performed approximately
260,000 diagnostic assays over an eight-month period.
In April 2002, as that effort
was starting to wind down, USAMRIID identified very low levels of anthrax
spores in a few localized areas outside of a containment laboratory. There
were no cases of illness due to anthrax exposure at the laboratory and
appropriate measures were taken to ensure the safety of the USAMRIID workforce.
Nonetheless, the incident highlighted the need for improvements in the
Institute's safety program.
The convergence of these events,
together with the FBI's widely publicized questioning of a scientist with
ties to USAMRIID as a "person of interest" in the anthrax letters case,
heightened scrutiny of the Institute and led some to speculate that the
material used in the attacks had originated at USAMRIID.
According to Henchal, his first
priority as commander was to raise the visibility of USAMRIID and re-establish
its reputation.
"People had misguided perceptions
about the Institute when I took over," he said. "USAMRIID was seen as the
source of the anthrax letters. My impression was that the staff was demoralized
and didn't know where we were going anymore. I think we are now recognized
as important contributors to biodefense for the country."
Biosurety guidelines
handed down
Shortly before Henchal took command,
the Department of the Army issued guidelines for its biosurety program,
a comprehensive effort to ensure the safe and secure use of biological
agents. The program encompassed physical security, biological safety, agent
accountability, and personnel reliability measures to prevent unauthorized
access to select agents of bioterrorism.
While USAMRIID already had efforts
in each of these areas, the Army guidelines imposed additional requirements.
Some were costly--like additional security cameras, x-ray machines and
other security measures. Others were burdensome--such as the "two man rule"
that required researchers accustomed to working independently to have an
observer present. In small labs that were crowded to begin with, this requirement
quickly proved unworkable.
Fortunately, USAMRIID was able
to broker a compromise in which security cameras took the place of the
"observer." To address the issue of containment laboratories where cameras
were not yet installed, the Institute created the Elite Roving Observer
Force, or EROF, a cadre of specially trained soldiers who have access to
any lab at any time and can monitor the research being performed. Henchal
credited LT. COL. Ross Pastel, his deputy commander for safety, biosurety,
operations, plans, and security, with helping to develop a workable biosurety
program.
"Something that not everyone at
USAMRIID appreciates is that biosurety protects us," Henchal said. "It's
not just a bureaucratic notion. We have a documented program--and if another
bioterrorism event happens, that program will protect us from the type
of criticism and speculation that we experienced in 2002."
In addition to strengthening physical
security at the Institute, and improving documentation of how biological
agents are stored and accessed, the biosurety guidelines called for a personnel
reliability program. USAMRIID had always performed background security
checks on personnel who worked in containment laboratories, but the new
program contains some additional requirements--including urinalysis and
enhanced medical screenings. While unpopular with employees, Henchal said,
a program like this is a necessary inconvenience in today's world.
"It's a burden--but ultimately
it allows us to do our work without suspicion," he added. "If we had not
been able to implement a viable biosurety program, we would have been shut
down."
Renewed emphasis
on safety
USAMRIID has a comprehensive safety
program that emphasizes safety training, risk management, environmental
surveillance, and occupational health screening. In the past 34 years,
there have been only five confirmed cases of laboratory-acquired infections.
Moreover, said Henchal, safety records for the past 3 years have documented
a steady decline in the annual rate of potential hazardous exposures from
about 16 to 4 per 1,000 personnel in the program. From the commander on
down, a culture of safety and risk management is encouraged at the laboratory.
That being said, the events of
2002 made it clear that some changes were necessary. Henchal directed a
reorganization of the safety office and mandated division chief involvement
in the safety committee. He stepped up regular safety meetings at the office,
division and Institute level.
"Safety has always been our number
one mission," said Henchal, "but before 2002, people seemed to think safety
was the job of the safety office. We emphasized that it was everyone's
responsibility."
At USAMRIID, every new laboratory
employee attends a safety workshop on laboratory operations, and annual
refresher training is required. Safety-related Minimum Essential Training
tasks are specified for each employee. Supervisors are held accountable
for the safety of their subordinates, and a safety standard is included
in the performance objectives of all USAMRIID employees.
In addition, the safety committee
meets regularly to review safety data and to propose methods to prevent
accidents. Safety concepts are emphasized by the publication of institute-wide
safety messages. The entire workforce receives risk management training.
Finally, according to Henchal, environmental monitoring for the presence
of biological agents now takes place both inside and outside containment
laboratories on a weekly basis.
Facility challenges...and
a new building
During Henchal's tenure, the USAMRIID
facilities have undergone several renovation projects totaling about $30
million. He called facilities manager Mr. Robert (Bob) Koning "a miracle
worker" in keeping the aging building running safely.
Among the highlights: the complete
renovation of a Biosafety Level 4 laboratory and containment clinical laboratory,
additional office space, and an expanded Center for Aerobiological Studies
that is slated to open in July. It features unique open suites, custom-designed
aerosol equipment, and an improved workspace design that will double the
Institute's capacity to do aerosol testing of vaccines and therapies in
animal models. This testing--a core capability of USAMRIID--is a critical
step in the process of obtaining Food and Drug Administration approval
of medical products for biodefense.
Even more exciting has been the
campaign to replace USAMRIID's aging facility, spearheaded by MAJ.
GEN. Lester Martinez-Lopez, former commander of the U.S. Army Medical Research
and Materiel Command. USAMRIID's existing facilities were built in the
1950's and 1960's for 325 personnel and now house more than 750 people,
according to Henchal.<
"Basically, our lab complex has
exceeded its life expectancy, and we are spending up to 25 percent of our
operating budget on maintenance costs," he said. "Most importantly, our
mission has expanded and the facilities we currently have are inadequate
to meet the demand."
The proposed new USAMRIID would
be constructed in two phases over a period of eight years. The programmed
amount is approximately $1 billion, which consists of $610 million for
Phase I and $405 million for Phase II. The total includes costs for design,
site work, construction, equipment, furniture, transition, relocation of
buildings in the footprint, and demolition of existing buildings.
USAMRIID has formed a project
team and is moving forward with the planning process, according to Henchal.
The first step will be preparation of an Environmental Impact Statement,
or EIS. A contract was awarded in April to begin the EIS process.
Cornerstone for
medical biodefense
Over the past three years, USAMRIID
has emerged as a cornerstone of the nation's interagency biodefense strategy.
In a series of U.S. House and Senate reports since September 2001, USAMRIID
is not only acknowledged as the military's premier biodefense laboratory,
but recognized as a national asset whose biocontainment facilities and
expertise provide critical support to the federal biodefense research system.
Efforts are currently underway
to establish a National Interagency Biodefense Campus at Fort Detrick that
will consist of several federal laboratories, including USAMRIID, the Department
of Homeland Security, the National Institute of Allergy and Infectious
Diseases (part of the National Institutes of Health), the U.S. Department
of Agriculture, and the Centers for Disease Control and Prevention. The
intent is that close proximity and shared resources will facilitate interagency
research on medical countermeasures, benefiting both civilian and military
populations.
"The campus is a reality," said
Henchal. "And coordination on the campus begins with coordination among
people. I think we have the elements now for scientific forums where scientists
can truly exchange information and decide where the best opportunities
are...the ones that can lead to breakthroughs."
Reflecting on his accomplishments
as commander, Henchal was quick to praise his staff.
"This is about USAMRIID--not about
me," he said. "If I had to point to one major accomplishment during my
tenure, it would be this: we prepared the Institute for its new role in
the biodefense community. We're on the cusp of a completely new era in
medical biodefense--the fruition of the National Interagency Biodefense
Campus. And everything we've done in the past couple of years has prepared
us for it."
Editor's Note: Coming
up in Part II: Henchal and USAMRIID Commander Col. George W. Korch, Jr.,
talk about USAMRIID's new way of doing business, including organizational
restructuring, changes in research programming, and creation of a civilian
scientific director for the Institute. They also discuss the challenges
facing USAMRIID in the next decade. |