| Study
of bioterror agents adds to risk
Funding to prevent
attacks like the 2001 anthrax crisis has given more people access to toxic
substances -- and brought more accidents.
By Jia-Rui Chong, Los Angeles
Times Staff Writer
October 3, 2007
The researcher at Texas A&M
University had never been trained to handle Brucella, a bacterium included
on the government's select list of potential bioweapon microbes.
Her work was in a different type
of bacteria, but when asked to help clean a chamber that had been used
to create an aerosol version of Brucella, she leaned inside and wiped it
down.
The bacteria entered her body
through her eyes, investigators later surmised. She was infected for more
than a month before doctors diagnosed her with brucellosis and put her
on a regimen of strong antibiotics.
The incident last year was part
of a small but unsettling number of laboratory accidents that has followed
a boom in research funding after the Sept. 11, 2001, terrorist attacks
and the still-unsolved anthrax mailings that came a week later.
The burst of money has spread
biodefense work to hundreds of university and research laboratories. In
some cases, the labs have been ill-prepared to work on the exotic microbes.
"Universities aren't set up to
handle these programs," said Edward Hammond, U.S. director of the Sunshine
Project, a nonprofit group in Austin, Texas, that tracks information on
biological weapons research. "I think we made a serious mistake putting
400 labs, thousands of people in the U.S., in the driver's seat behind
biological weapons."
All told, there have been 111
cases involving potential loss of bioagents or human exposure reported
since 2003 to the national Centers for Disease Control and Prevention or
the U.S. Department of Agriculture.
The incidents include the potential
exposure of 12 laboratory workers to live anthrax bacteria after an incorrect
sample was sent to Children's Hospital Oakland Research Institute in 2004,
the infection of three researchers at Boston University in 2004 after they
mistakenly handled a sample of live tularemia bacteria, and the disappearance
of a mouse infected with Q fever at Texas A&M in 2006.
Federal officials say that the
overall number of incidents is small, and they emphasize that no one has
died -- and that no one beyond laboratory workers has been infected.
"If you're looking at the total
amount of work in these labs, it strikes me that 100 incidents is very
low," said Dr. Richard E. Besser, director of the CDC's Coordinating Office
for Terrorism Preparedness and Emergency Response. "Full investigations
were done, and none of the events were thought to put the public at risk."
But Richard Ebright, a microbiologist
at Rutgers University who has been monitoring biodefense safety issues,
said that given the potential danger of the materials, the number of accidents
is, in some ways, immaterial.
"Twenty-five incidents per year
does not represent a good record," he said. "It only takes one incident
in which a highly transmissible agent is introduced into a human population
to produce a catastrophic loss."
Following the money
Before 2001, experts say much
of biodefense research took place in government laboratories, such as the
U.S. Army Medical Research Institute of Infectious Diseases at Ft. Detrick
in Maryland. There, scientists in full-body suits worked in containment
laboratories developing vaccines for some of the world's most hideous diseases,
such as Ebola, Marburg hemorrhagic fever, anthrax, smallpox, tularemia
and Lassa fever.
Then, everything changed. A week
after the Sept. 11 attacks, letters containing anthrax spores began appearing
around the country. Five people died and 17 others were infected.
The incident prompted Congress
to dramatically increase biodefense funding. Research money from the National
Institute of Allergy and Infectious Diseases, which administers a major
portion of biodefense funding, has grown from $187 million in 2002 to $1.6
billion in 2006.
Scientists followed the money.
The CDC now counts about 14,000 researchers registered to work with so-called
"select agents."
Biodefense experts were worried
from the beginning about the expansion.
Increasing the number of laboratories
increased the chances of an accident, experts said. Ebright said that the
expansion also raised the problem of spreading the deadly knowledge of
bioagents to potential terrorists.
Some of the early fears have not
materialized. For example, there have been no confirmed thefts or losses
of bioagents.
"We're in a much better place
now than we were four years ago," the CDC's Besser said. "Now we have really
strong requirements about who is allowed to work with these agents and
what kinds of safety and security are in place."
In 2002, new federal rules required
biodefense researchers to register their labs with the CDC or USDA to work
with the agents, and pass a Department of Justice background check. They
were also required to devise safety plans and report accidents to the government.
Still, concerns linger that the
rules are inadequate. Congress has begun investigating the issue, and a
hearing in Washington is scheduled for Thursday.
"There are no clear rules about
training, ability or the orientation of the lab to handle these matters,"
said Rep. John D. Dingell (D-Mich.), chairman of the House Energy and Commerce
Committee.
"There are bills for funding and
for research, yet nobody knows what regulation there is, how the regulations
work and whether they are safe," he said. "There is a culture of secrecy."
The results of government inspections
have not been encouraging. A 2006 report by the inspector general of the
Department of Health and Human Services found 11 out of 15 universities
did not fulfill all the federal requirements. Several universities kept
sloppy inventory records, and inspectors could not identify who was gaining
access to the pathogens, according to the report.
Institutions working on animal
and plant pathogens did worse. None of the 10 institutions described in
a 2006 report by the USDA inspector general met all standards. Many had
not updated their lists of people with access to the pathogens and had
failed to fully train their staffs.
Potential for disaster
Many of the accidents have been
relatively mundane. Most would be small events if not for the danger of
the agents involved.
In May, a researcher at the University
of Texas Health Science Center at Houston was working with anthrax in a
centrifuge. When the machine began clanking, the researcher opened the
cover and saw liquid spilled inside.
She and three others in a nearby
room tested negative for anthrax, and no spores were found in the lab,
university officials said.
"It was a rookie mistake," said
Robert Emery, assistant vice president for safety, health, environment
and risk management at UT Houston. "We exist to teach people to treat and
prevent disease. Part of that is a lack of knowledge about technique and
learning it."
Among the most serious incidents
were the infections of three researchers at Boston University in 2004.
They thought they were working on an inactivated vaccine strain of the
bacterium Francisella tularensis, but actually were handling a virulent
form that had been mistakenly sent by another laboratory.
The researchers all recovered,
but it took months for doctors to diagnose their potentially fatal disease
because its symptoms -- coughs, fever, headaches -- are common.
The Brucella case at Texas A&M
turned out to be only the beginning of the university's troubles. When
the CDC began investigating in April -- a year after the incident -- the
university disclosed that three lab workers had blood tests in 2006 showing
higher-than-normal levels of antibodies for Q fever, a disease caused by
the bacterium Coxiella burnetii.
The researchers never showed any
symptoms, so the university thought it did not have to report the cases,
the university's interim president Eddie J. Davis told reporters in July.
The CDC found other problems,
and on Aug. 31 suspended all work with select agents at the university,
the first and only suspension issued by the agency.
Despite the punishment, Hammond,
of the Sunshine Project, said the case was another example of how the biodefense
program had grown too fast and too large for the government to adequately
manage.
The system "is not really working,"
he said. "The explosion of biodefense programs is creating dangers."
Dr. Alan Barbour, a UC Irvine
professor who directs a federally funded regional center for biodefense
and emerging diseases, said national training standards must be adopted
for bioagents.
"I'm a physician, and I'm used
to dealing with people in the hospital," Barbour said. "If you make a mistake,
someone could die. I think some people are not used to handling things
that way. They're going to have to learn."
jia-rui.chong@latimes.com |